|
Symbol Name ID |
Cyp11b1
cytochrome P450, family 11, subfamily b, polypeptide 1 MGI:88583 |
| Darker colors indicate more annotations |
| Human Phenotypes | Type I diabetes mellitus |
Type II diabetes mellitus |
Increased circulating androstenedione concentration |
Increased circulating dehydroepiandrosterone-sulfate concentration |
Increased serum testosterone level |
Increased circulating 17 hydroxypregnenolone concentration |
Elevated circulating 17-hydroxyprogesterone concentration |
Elevated circulating 21-deoxycortisol concentration |
Elevated serum 11-deoxycortisol |
Adrenal hyperplasia |
Congenital adrenal hyperplasia |
Impaired cortisol response to corticotropin releasing hormone stimulation test |
Decreased circulating renin level |
Increased circulating renin level |
Adrenal insufficiency |
Decreased circulating aldosterone level |
Hyperaldosteronism |
Adrenogenital syndrome |
Precocious puberty in males |
Premature pubarche |
| Disease(s) Associated with CYP11B1 | ||||||||||||||||||||
| congenital adrenal hyperplasia | ||||||||||||||||||||
| glucocorticoid-remediable aldosteronism | ||||||||||||||||||||
| primary hyperaldosteronism | ||||||||||||||||||||
| Disease(s) Associated with CYP11B2 | ||||||||||||||||||||
| corticosterone methyloxidase deficiency 1 | ||||||||||||||||||||
| pre-eclampsia | ||||||||||||||||||||
| primary hyperaldosteronism | ||||||||||||||||||||
| type 2 diabetes mellitus | ||||||||||||||||||||
| Mouse Phenotypes | abnormal adrenal cortex morphology |
increased adrenal gland zona fasciculata size |
abnormal adrenal gland zona glomerulosa morphology |
abnormal adrenocortical cell morphology |
enlarged adrenal glands |
adrenal gland hyperplasia |
pituitary gland hyperplasia |
decreased thymus weight |
absent corpus luteum |
|
| Availability | Mouse Genotype | |||||||||
| Cyp11b1tm1Chjk/Cyp11b1tm1Chjk | ||||||||||
| Cyp11b2tm1Hsk/Cyp11b2tm1Hsk | ||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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